Welcome to Me is about a year in the life of Alice Klieg (Kristen Wiig), a woman with Borderline Personality Disorder who wins the lottery, quits her meds and buys herself a TV show where she talks only, and exclusively, about herself.
Unlike anything that's been on TV before, it becomes a public forum for Alice to explain, complain, sing, cook, and even neuter dogs. She tears through money, broadcasting for longer and longer periods until she's televised 24/7, even while she sleeps.
When the consequences catch up with her, she cracks and finds herself truly alone. All that's left is her show, which she must use to win everyone back.